Study Links Breast Implants to Lung and Brain Cancers

A long- running study has found that while women with breast implants are not at increased risk for most cancers, they appear to suffer higher rates of lung and brain cancer than other plastic surgery patients, researchers at the National Cancer Institute said today. The study demonstrated only a link between implants and the two types of cancer, not a cause-and- effect relationship, and its significance is unclear, said the lead author, Dr. Louise A. Brinton, chief of the cancer institute’s environmental epidemiology branch. “What the study showed is no difference for most of the cancer sites, which I think is good news,” Dr. Brinton said. “And for the few sites which we did find differences, we have no ready explanation. So I would not want to alarm women on the basis of one study.” Nonetheless, the results are likely to inflame the debate over the safety of breast implants. “I see this as a warning,” said Dr. Diana Zuckerman, director of the National Center for Policy Research for Women and Families, who served on the study’s scientific advisory panel.

 

“You can’t draw a conclusion from these studies, even though they are very well designed, very solid,” said Dr. Zuckerman, who nonetheless added, “I think this is very alarming.” Dr. Brinton’s group identified nearly 13,500 women who received breast implants before 1989 and followed them for an average of 13 years. The women were compared with a control group of 4,000 other plastic surgery patients and with the general population. The study results, which focused on a comparison between the breast implant patients and the plastic surgery control group, were based on questionnaires completed by 7,500 of the women, as well as medical records and, in some cases, death certificates. The women’s average age when they received their implants was 34, and all had implants for at least eight years. Most had silicone implants, which the Food and Drug Administration removed from the market in 1992; about 10 percent had saline implants.

 

The researchers found that the type of implant made no difference in a woman’s cancer risk. Results from the study appear this month in two medical journals: Epidemiology, and Annals of Epidemiology. It found that women in the implant group were three times as likely to die of diseases of the respiratory tract, primarily lung cancer, as the women in the plastic surgery control group, and twice as likely to die of brain cancer. A separate analysis of the number of malignancies, as opposed to deaths, also found higher rates of lung and brain cancer in women with implants. Previous research has suggested that women with implants may be at increased risk for lung problems, and some experts have theorized that silicone gel, which coats even the saline implants, migrates to the lung. But Dr. Brinton said she could not rule out smoking as a factor. In her study, the implant patients and the women who had had other plastic surgery reported the same rates of smoking. But most of the lung cancer information was gleaned from death certificates, so it was impossible for researchers to know whether those women smoked. “We couldn’t fully account for smoking differences,” Dr. Brinton said. As to the brain cancer finding, she said, researchers do not have a plausible explanation for it, and so further research is necessary.

Oranges, Bananas And Turmeric Prevent Leukaemia

Giving infants oranges and bananas regularly may halve their risk of developing childhood leukaemia, suggest the results of a new study. And a diet containing the curry spice turmeric may also be protective – accounting for the differences in childhood leukaemia rates between east and west – says a leading scientist.

 

Children who ate oranges, orange juice or bananas between four to six times a week during their first two years of life had a significantly reduced risk of developing the cancer, revealed the observational study by US researchers. Previous studies on childhood leukaemias have not examined the effects of the overall diet in this way, focusing more on possible risk foods like cured meats. “Our study is unique, and we have elucidated a significant protective association with the consumption of oranges, bananas and orange juice,” says Marilyn Kwan, an epidemiologist at the University of California, Berkeley.

 

However, she cautions that without carrying out a randomised controlled trial, it is difficult to predict exactly how protective eating these fruits may be, or to make firm public health recommendations. But she notes that in her study “there was a 50 per cent reduction in risk”. The evidence for oranges and bananas, and turmeric in preventing leukaemia was presented at Children with Leukaemia’s international leukaemia conference in London, UK, on Thursday.

Smokers ‘will die 10 years early’

Smoking cigarettes cuts an average of 10 years off a person’s life, a landmark study suggests. But it also shows that quitting at any age reduces the risks of dying from smoking-related diseases. The findings, published in the British Medical Journal, are the culmination of a 50-year study involving 34,439 men. The study, which began in 1951, was the first to confirm the link between smoking and lung cancer exactly 50 years ago. All of those involved in the study were born between 1900 and 1930 and all worked as doctors.

 

They were each asked about their smoking habits at the start of the study in 1951. Researchers contacted them periodically over the next 50 years to see if those habits had changed. Since the study began in 1951, tobacco has killed around 100 million people Professor Alex Markham, Cancer Research UK They also gathered information on those who died during the period. They have now analysed that data. They found that men who have never smoked lived on average 10 years longer than those who smoked for most of their lives. Men who smoked were at least twice as likely to die before the age of 70 as non-smokers. They were up to three times more likely to die before they were 90 compared to those who never took up the habit. The average age of these men when they started smoking was 18. On average, they said they smoked around 18 cigarettes a day.

 

It was already known that about half of all persistent cigarette smokers are killed by their habit, a quarter while still in middle age (35-69 years). The biggest killers are cancer, heart disease and stroke. But the study also revealed that giving up cigarettes at any age has major health benefits. It found that men who had stopped smoking by the time they were 30 lived as long as those who never smoked. Those who quit at 40, lived just one year less than those who had never smoked. Those who stopped smoking at 50 added six years onto their lives, while those who kicked the habit at 60 added an extra three years to their life.

How Quackery Harms Cancer Patients

The amount of money wasted on cancer quackery is unknown but probably exceeds one billion dollars per year — the amount spent for cancer research. The financial impact upon individuals and families can be catastrophic if they fall into the trap of heroically “leaving no stone unturned” in their quest for a remedy in hopeless cases. Some quacks are quite willing to bleed them dry financially. I know of cases in which survivors were deprived of the family’s savings, were left with a large mortgage on a previously paid-for home, or even lost their home. Dubious therapies can cause death, serious injury, unnecessary suffering, and disfigurement.

 

Cyanide poisoning from ingesting apricot pits or laetrile, Salmonella dublin infection from drinking raw milk, electrolyte imbalance caused by coffee enemas, internal bleeding from deep body massage, and brain damage from whole-body hyperthermia have all caused needless death of cancer patients. At clinics providing substandard care, intravenous infusions of various concoctions have caused septicemia and malnutrition. And the application of escharotics (corrosive chemicals) to the skin of cancer patients has resulted in needless disfigurement. Ruth Conrad, an Idaho woman, had a horrible experience as a result of consulting one of the state’s many unlicensed naturopaths. While seeking treatment for a sore shoulder, she also complained of a bump on her nose. The naturopath stated that it was cancer and gave her a black herbal salve to apply directly.

 

Within a few days, her face became very painful and she developed red streaks that ran down her cheeks. Her worried phone call to the naturopath brought the explanation that the presence of the lines was a good sign because they “resemble a crab, and cancer is a crab.” He also advised her to apply more of the black salve. Within a week, a large part of her face, including her nose, sloughed off. It took three years and 17 plastic surgical operations to reconstruct her face. Mrs. Conrad’s experience illustrates another aspect of cancer quackery — fake diagnosis. She never had cancer in the first place. In addition to suffering direct harm from a caustic treatment, she also suffered the mental anguish of thinking she had a dread disease.

Cigarette smoke transforms healthy saliva into a deadly cocktail

Cigarette smoke transforms healthy saliva into a deadly cocktail that can accelerate mouth cancer, according to research in the British. New research shows that the chemicals in tobacco smoke combine with saliva with devastating effect. They destroy the protective components of saliva – leaving a corrosive mix that damages cells in the mouth and can eventually turn them cancerous. There are nearly 8,000 cases and 3,000 deaths from mouth cancer in the UK every year – the main cause being smoking. Mouth cancer can develop in any part of the mouth including the tongue, gums, lining of the mouth and lips. The researchers in the study wanted to examine saliva’s role in the development of mouth cancer. Around 90 per cent of lung cancer cases are caused by tobacco smoking and other studies show that smoking can cause a range of other cancers including cancer of the pancreas, stomach, liver and lower urinary tract. The study recreated the effects of cigarette smoke on cancerous cells of the mouth.

 

Half the cell samples were exposed to cigarette smoke and the other half to the saliva and cigarette smoke mixture. Cancerous cells were used in order to assess quickly whether the saliva and smoke mixture would speed the cancer’s development. The study revealed that the longer the mouth cells were exposed to the contaminated saliva, the more the cells were damaged. Dr Rafi Nagler of the Technion-Israel Institute of Technology, who co-led the study, says: “Most people will find it very shocking that the mixture of saliva and smoke is actually more lethal to cells in the mouth than cigarette smoke alone. “Our study shows that once exposed to cigarette smoke, our saliva not only loses its beneficial qualities but it turns traitor and actually aids in destroying the cells of the mouth and oral cavity.” Saliva contains anti-oxidants.

 

These are molecules that can help protect the body against cancer. The researchers found that the cigarette smoke destroyed them and turned saliva into a dangerous cocktail of chemicals that could accelerate the development of mouth cancer. Control for Cancer Research UK said “Once more we see the dreadful impact smoking can have on health. This insight into how mouth cancer can develop offers more reasons for smokers to try and quit. People know of the link with lung cancer, and this research adds compelling evidence about the damage smoking can do to the mouth.”

ETS Exposure in Infants and Children

Studies dating from the early 1970s have consistently shown that children and infants exposed to ETS in the home have significantly elevated rates of respiratory symptoms and respiratory tract infections. More than 50 recently published studies confirm these previous conclusions: ETS exposure due to parental smoking, especially the mother’s, contributes to 150,000 to 300,000 cases annually of lower respiratory tract infection (pneumonia, bronchitis, and other infections) in infants and children under 18 months of age; 7,500 to 15,000 of these cases require hospitalization. ETS exposure is associated with increased respiratory irritation (cough, phlegm production, and wheezing) and middle ear infections, as well as upper respiratory tract symptoms (sore throats and colds) in infants and children.

 

ETS exposure increases the number of episodes and the severity of asthma in children who already have the disease. The EPA report estimates that ETS worsens the condition in 200,000 to 1 million asthmatic children. Moreover, ETS exposure increases the number of new cases of asthma in children who have not previously exhibited symptoms. ETS exposure “in utero” and in infancy can alter lung function and structure and create other changes that are known to predispose children to long-term pulmonary risks. In the United States, sudden infant death syndrome (SIDS) is the major cause of death in infants between the ages of 1 month and 1 year, and the linkage with maternal smoking is well established.

 

Current evidence strongly suggests that infants whose mothers smoke are at an increased risk of dying of SIDS. This risk is independent of other known risk factors for SIDS, including low birth weight and low gestational age, both of which are specifically associated with active smoking during pregnancy. Additional studies are needed to determine whether the increased risk is related to “in utero” or postnatal exposure to tobacco smoke, or to both. These findings prompted recommendations that ETS be eliminated from the environment of small children. Thus, smoking should not be allowed in day care centers, nurseries, or other settings where infants and young children are cared for.

Genes and bladder cancer

Arylamines are known bladder carcinogens and are an important constituent of tobacco smoke. The handling of arylamines in the body is complex and includes metabolism by NAT1 and NAT2, enzymes that play a role in both activation and detoxification of arylamines and their congeners. Both NAT1 and NAT2 are polymorphic, with alleles that have been shown to correlate with higher or lower enzyme activity. To explore the combined role of these genes and exposure on bladder cancer risk, we examined the NAT1 and NAT2 genotype in a case-control study of bladder cancer in which detailed exposure histories were available on all 230 cases and 203 frequency-matched controls. Using PCR-RFLP genotyping, we determined NAT2 genotype for the five most common alleles, NAT2*4, NAT2*5, NAT2*6, NAT2*7, NAT2*14 (frequently referred to as WT, M1, M2, M3, and M4, respectively).

 

Similarly, the NAT1 genotype was determined for the four most common alleles NAT1*3, NAT1*4, and NAT1*11, and the putative high-activity allele, NAT1*10. No association between NAT2 genotype and bladder cancer risk was found whether genotype was considered alone or in combination with smoking, in either stratified or logistic regression analysis that adjusted for age, sex, and race. Stratified and logistic regression analysis both demonstrated an increased risk for individuals carrying the NAT1*10 allele among smokers. There was evidence of a gene-dosage effect, such that those who were homozygous for the NAT1*10 allele had the highest risks.

 

There was also evidence of a statistically significant gene-environment interaction, such that bladder cancer risk depends on both NAT1 genotype and smoking exposure. Interestingly, although NAT2 genotype did not influence risk either alone or in combination with smoking exposure, there was evidence of a statistically significant gene-gene-environment three-way interaction. Bladder cancer risk from smoking exposure is particularly high in those who inherit NAT2 slow alleles in combination with one or two copies of the NAT1*10 allele. A biological mechanism for this finding is suggested.

Cause of cancer

Researchers working in England claim to have found the cause of cancer. Whether they actually have or not remains to be seen, but they say it is caused by a virus (honest.. that’s what they said!). They also claim that because of it’s virul foundations, they should be able to develope a vaccine to protect against the condition. If they are correct, then they have probably made one of the biggest medical breakthroughs in years, and it is extremely good news for those who do not have cancer and wish to avoid contracting it. It would be, however, extremely bad news for those who are of the mistaken belief that smoking causes cancer, as they would have to totally rethink their outlook on life, and the discrimination they are being allowed to display to smokers.

 

Yes, it’s true that viruses are associated with certain human and animal cancers. However, this isn’t a new discovery. I believe the first oncogenic (cancer-causing) virus may have been the avian Rous Sarcoma Virus described by Peyton Rous in the late 1950s. Viruses are known causes of animal leukemias (e.g. bovine leukemia virus, feline leukemia), and very likely at least some human leukemias, but the evidence was less developed for this human disease the last time I read into it some years ago. Human papilloma viruses cause benign skin tumors (warts) , which may progress to a malignant state, and are also associated such malignant tumors as cervical cancer. Most major cancer research centers have a viral oncology group at work- this is a well-developed research area.

 

It’s important to remember that cancer isn’t one disease, it is a family of diseases which share an essential feature of cell division without normal restraints like inhibition by neighboring cells and programmed cell death (apoptosis). Yes, certain viruses are associated with cancer, as are certain chemical exposures, lifestyle factors, dietary habits, genetic factors, etc. These are all concurrent realities and aren’t mutually exclusive. Viruses can cause leukemia, so can benzene, so can ionizing radiation. Viruses may interact with environmental carcinogens to potentiate cancer risk, e.g. chronic hepatitis B and aflatoxin consumption affecting liver cancer risk in some parts of the world.

Babies born to smoking mothers should be considered ex-smokers

Newborns whose mothers smoke during pregnancy have the same nicotine level as grown-up smokers and almost certainly spend their first days of life going through withdrawal, a new study finds. “The baby of a smoking mother should be considered to be an ex-smoker,” said Dr. Claude Hanet of St. Luc University Hospital in Brussels. The study, conducted principally by Dr. Laurence M. Galanti of Mont-Godinne University Hospital in Namur, Belgium, was presented Wednesday at a meeting of the American College of Cardiology. In the United States, smoking during pregnancy is on the decline. But the latest data show that 15 percent of women still use cigarettes while pregnant. Exposure to tobacco in the womb stunts fetal growth so babies are born small.

 

After birth, these babies are more likely to suffer sudden infant death or have lung trouble, among other health problems. Robert Merritt, a behavioral scientist at the U.S. Centers for Disease Control and Prevention in Atlanta, said the latest data “support what we have been saying all along: Smoking is not good for you, period.” The study was conducted on 273 children, including 139 babies just one to three days after birth. The researchers checked their urine for cotinine, the substance that remains when nicotine breaks down in the body. It lingers for several days after exposure to nicotine. Cotinine levels in the newborns of smoking mothers were about 550 nanograms per milligram of urine, virtually the same as the level found in the smoking women. Amounts in toddlers with smoking mothers were much lower–about 200 nanograms–but still considerably higher than in adult nonsmokers exposed to smoke at home.

 

“These data underline the importance of prevention programs intended to reduce exposure of children to tobacco smoke,” Galanti said. Virtually everything in the mother’s bloodstream is passed to her fetus during development in the womb, including all the chemicals in tobacco smoke. Another study, released last April at a meeting of the American Association for Cancer Research in Washington, found that even nonsmoking women who inhale other people’s cigarette smoke can pass cancer-causing chemicals to their fetuses.

War on tobacco rages on multiple fronts

It was a breath of fresh air, and appropriately so, in the middle of a news conference loaded with understandably dense scientific topics. Dr. Paul Bunn, a Denver oncologist who specializes in lung cancer research, made it clear that he wanted to take the burden from lung cancer patients who torture themselves over their cigarette smoking. Ninety percent of lung cancers are caused by tobacco smoke, he acknowledged, and nearly twice as many women die of lung cancer as die of breast cancer. But the fault doesn’t truly lie with those who have been long-term smokers, he said.

 

“The greed of the tobacco companies induced these cancers.” Dr. Bunn, the new president of the American Society of Clinical Oncology (he made his statements at the group’s recent annual meeting,) says the society has been an advocate of regulating tobacco sales for several years. And considering that so many of its members are doctors who deal with the after-effects of tobacco consumption, it’s no wonder. Why, I asked him one early morning as he talked with me by cell phone, shouldn’t smokers be responsible for their own actions? After all, and this is always the claim, no one held a gun to their heads and forced them to puff away for 20 or 30 years. “Nicotine is an addicting drug,” he said.

 

“The most addicting drug in the world. Other addicting drugs are illegal. This one is marketed and sold to teens.” If we give kids weapons, he was saying, and glue them to their hands, expect them to kill themselves. And maybe others through secondhand smoke? He wants nicotine regulated by the U.S. Food and Drug Administration, the way other substances are controlled. But he, and presumably his organization, won’t stop there. He also wants some international action taken, and after meeting with representatives of groups like the American Cancer Society while at his own annual meeting, he said, “We intend to be active on international policies.”