Incense burning ‘may cause cancer’

Think twice before lighting that next stick of incense. You might be getting more than a gentle whiff of sandalwood. If a group of researchers in Taiwan is right, burning incense could be a cancer risk. This news might come as a shock to millions of Buddhists, Hindus and Christians who use incense to purify the air, set their minds at ease and treat diseases, and as part of their ceremonies and devotions.

 

At the Lantau Island Po Lin Monastery in Hong Kong, visitors burn about three sticks each as they pay their respects to the Buddha and their ancestors, feeding their spirits with incense, according to a spokeswoman. Others in Japan stand in front of giant vats and breat he in the scent of hundreds of incense sticks to get wise or just for good measure. “We truly hope that incense burning brings only spiritual comfort, without any physical discomfort,” Ta Chang Lin at the National Cheng Kung University in Tainan told the New Scientist magazine. But “there is a potential cancer risk. We just cannot say how serious it is.”

 

Smoke from burning incense is laden with cancer-causing chemicals, the researchers say. Levels of one chemical believed to cause lung cancer were 40 times higher in a badly ventilated temple in Taiwan than in houses where people smoke cigarettes. Beyond the cancer scare, incense is actually bad for the air. Incense burning creates more pollution than road traffic at a local intersection. In the smoky temple they tested, the incense emissions exceeded the standard “safe” levels for ambient air set in Taiwan.

DNA repair technique could boost cancer treatment

Scientists have worked out how a key molecule could be encouraging the re-growth of cancer cells. The molecule AlkB uses a particular chemical process called oxidative demethylation to repair DNA. It relies on the presence of iron and several other chemicals. AlkB could be preventing the success of some conventional cancer treatments, which attack tumours by damaging their DNA.

 

Scientists hope interfering with its activity could therefore bring major advances in chemotherapy and other methods of fighting cancer. Lead researcher Dr Barbara Sedgwick of Cancer Research UK said: “The process for repairing DNA has been studied intensively for many years now, so to discover a completely new mechanism of action was both surprising and very exciting.” “We think the AlkB molecule could be one of the major reasons for resistance to chemotherapy and now that we know how it works, it should be possible to find ways to overcome this problem,” she added.

 

She said the discovery was likely to have a number of important implications for the treatment of cancer. She said: “It might be possible to use AlkB to protect cells in the bone marrow that can otherwise get damaged by chemotherapy, which may reduce the side-effects of treatment.” A spokesman for Cancer Research UK, said: “Sometimes our natural repair systems get in the way and cause resistance to treatment. One of those systems involves AlkB so knowing how the molecule works is an important development.”

Plant Compound Kills Brain Tumor Cells

A chemical isolated from a weed that grows in mountain meadows in the western United States kills the cells of an aggressive brain cancer that affects some children. The compound, cyclopamine, blocks a signaling pathway that appears to be important for the survival of medulloblastoma, a form of cancer for which there is no effective treatment. In an article published in the August 30, 2002, issue of the journal Science, a research team led by Howard Hughes Medical Institute investigator Philip A. Beachy reported that cyclopamine effectively killed cultured mouse medulloblastoma cells and tumors implanted in animals, as well as medulloblastoma cells extracted from human tumors. “It will be difficult to obtain sufficient quantities of cyclopamine, since it must be extracted and purified from the plant source, Veratrum californicum, the corn lily,” said Beachy, who is at The Johns Hopkins University School of Medicine.

 

“However, we believe that with this study, the evidence is in place to justify an effort to develop a supply so that it can be tested in humans.” Beachy and his colleagues at Johns Hopkins collaborated with researchers from the Fred Hutchinson Cancer Research Center and the University of Washington/Children’s Hospital in Seattle. Beachy said there are some parallels between cyclopamine and taxol, a drug used to treat breast cancer drug that was initially in short supply because it had to be isolated from the bark of the Pacific yew tree. However, as taxol proved clinically effective, researchers developed an alternate method of partial synthesis of the compound from a more plentiful precursor in the needles that made the drug available in sufficient supply.

 

Beachy and his colleagues began to explore whether cyclopamine would be effective against medulloblastoma after studies by several groups, including HHMI investigator Matthew Scott and his colleagues at Stanford University, showed that both animals and humans developed tumors, including medulloblastomas, when the Hedgehog signaling pathway was activated. The pathway — named for its key regulatory protein Hedgehog — has long been known to be critical for the growth and differentiation of cells during embryonic development. Scott and his colleagues showed that the tumors they studied consisted of cells that had most likely reverted to a highly proliferative embryonic state, due to a mutation that enabled the activation of the Hedgehog pathway.

Fast Growth Increases Teenage Cancer Risk

Teenagers are growing so fast because of better diets and a higher standard of living that their risk of cancer may be increasing, specialists said yesterday. Among young people aged 13 to 24, cancer has increased by more than a quarter in 20 years and by almost half in the past three decades. The disease is now the biggest natural cause of death in the age group and overall, second only to accidents. Some cancers, such as melanoma, have doubled in 20 years and are linked to changing lifestyles, such as the rise in holidays in the sun. But for other common cancers among teenagers, such as leukaemia and testicular cancer, the causes are unclear. Overall, the incidence of teenage cancer rose at 1.2 per cent a year between 1979 and 2000 and now accounts for 2,000 new cases a year.

 

Speaking at the third international conference on teenage cancer in London yesterday, Professor Archie Bleyer, director of community oncology at the University of Texas, said increases in the height and weight of young people over the past half century were likely to be a factor behind the rise. Growth was caused by cell division and cancer occurred when the process of cell division suffered a breakdown and went out of control, he said. “This increasing growth rate, with an increasing number of cell divisions, means there are more chances for cancer to develop. It is the trade-off for a rising standard of living,” he said. Studies had shown that the size of a baby at birth was linked to its chances of getting cancer in childhood. “The faster the baby grows in the womb and the bigger it is at birth the more likely it is to develop cancer in early life. If it continues to grow rapidly it may be more prone to cancer later on,” Professor Bleyer said.

 

Charles Stiller of the childhood cancer research group at the University of Oxford, said bone cancer was the only cancer which peaked in the teenage years. “Although teenage cancer follows a distinctive pattern, no other cancer is distinctive of that group,” he said. The hypothesis that increasing growth rates among young people was linked to the rise in cancer had yet to be proved, Dr Stiller said. As young people had not lived long enough to suffer prolonged exposure to environmental agents, the likeliest cause of their cancer was a genetic susceptibility, he said. Myrna Whiteson, chairman of the Teenage Cancer Trust, said the needs of young cancer sufferers were being ignored and survival rates had barely increased in 25 years. “It’s a lottery where they are treated and by whom. We consider our teenagers have been failed by the Government,” she said.

Child cancers have common cause

A common infection could cause brain and lymphatic cancers in children, researchers have suggested. They say that is the most likely explanation for the clustering of cases that they have seen. The finding means doctors will be able to now investigate common origins of the different cancers in children. Experts from Cancer Research UK looked at the incidence of childhood cancer cases across the north west of England over the last 50 years. They told the European Cancer Conference in Copenhagen that the pattern of cases they saw could not be explained by chance. Researchers looked at around 5,000 cases of all childhood cancers that had occurred in the north west from 1954 and 2001.

 

They found cases of Hodgkin’s Disease, a cancer of the lymphatic system, and a kind of brain tumour called astrocytoma occurred in the same areas and time periods much more frequently than would have been expected. Clusters were defined as covering children born within a year of each other and living within 5 km of each other when they were born. The same kind of clustering was seen with Acute Lymphoblastic Leukaemia (ALL) and astrocytomas and with ALL and Non-Hodgkin’s Lymphoma. The figures were adjusted to take account of the differences between built-up and rural areas. Although most of the clusters were small, typically around three or four cases, the researchers from the Cancer Research UK Paediatric and Familial Cancer Research Group at the Royal Manchester Children’s Hospital said the frequency of the clusters was unusual.

 

The team had previously found separate clusters of childhood brain cancers and ALL. Dr Richard McNally, who led the research, told BBC News Online: “We found something that’s not random, that isn’t likely to be a chance occurrence. “It’s the first time we’ve found these clusters so the big step forward is that it points to a common factor between these cancers. “We would infer that it’s to do with something sporadic, some sort of occasional environmental exposure. “The obvious cause would be infections, which come and go in waves. “It could be that these cancers result as a rare consequence of exposure to certain infections.”

Leukaemia risk for kids living near petrol stops

Children who live next to a petrol station are four times more likely to develop acute leukaemia than other children in the same area, suggests new research. The small study, carried out at four sites in France, looked at 280 children with leukaemia and a control group of 285 children, all younger than 15 years. The children’s mothers were given a questionnaire relating to their lifestyle. The researchers found that children living next door to a petrol station or automotive garage had a quadrupled risk of leukaemia. And the risk of developing acute non-lymphoblastic leukaemia was seven times greater compared with children who lived in the same area, but not next to a petrol station.

 

“I was very surprised that living near a petrol station had such a high risk,” says Jacqueline Clavel from the National Institute of Health and Medical Research in Villejuif, France, who led the study. “The longer the child had lived in the vicinity of the petrol station, the higher their relative risk was. Prenatal exposure also raised the relative risk.” Clavel suspects benzene in petrol caused the rise in cancer risk, although she says further studies need to be done. “The link between benzene and leukaemia has been shown for workers in a rubber factory, but the benzene levels are very high in that instance. Exposure to benzene is much lower for children near a petrol station, so it was surprising,” she told New Scientist. Richard McNally, from Cancer Research UK’s paediatric and familial cancer research group, says that while the findings are interesting, they should be treated with caution.

 

“The study examined a relatively small number of leukaemia cases, and the fact that it was based on interviews leaves it open to influences such as inaccuracy in the recollections of the mothers interviewed,” he says. Although it is the most common childhood cancer in the western world, acute leukaemia is rare, with four new cases per 100,000 children each year. The majority of cases occur in two-year-old infants, but more than 80 per cent of children make a full recovery.

Tobacco is responsible for a third of all UK cancer deaths

Sir Richard Doll, who has been involved in the study since the start, said smoking was still a major killer in the UK. “Over the past few decades prevention and better treatment of disease have halved non-smoker death rates in the elderly in Britain. “But these improvements have been completely nullified by the rapidly increasing hazards of tobacco for those who continue to smoke cigarettes.” Sir Richard Peto, professor of medical statistics and epidemiology at Oxford University has collaborated on the study for 30 years. He said smoking was responsible for millions of death. “Partly because of earlier results from this 50-year-long study many people in Britain gave up smoking, and this country now has the best decrease in tobacco deaths in the world.

 

“But, in many countries tobacco deaths are still going up. In Britain, tobacco has caused six million deaths over the last 50 years. But, worldwide, tobacco will soon be causing six million deaths each year.” Professor Sir Charles George, medical director of the British Heart Foundation, welcomed the study. “It provides a clear demonstration of the harmful effects of persistent cigarette smoking, which on average shortens life by around 10 years. “Both for heart disease and for cancer the benefits of stopping smoking are clear cut and the earlier this occurs, the better.” Professor Alex Markham of Cancer Research UK said: “Tobacco is responsible for a third of all UK cancer deaths. Since the study began in 1951, tobacco has killed around 100 million people globally.”

 

Professor Colin Blakemore, chief executive of the Medical Research Council, said: “Fifty years ago, the findings of this unique study had a major impact on our understanding of the links between smoking and disease. “These new findings complete the picture on smoking-related deaths.” Simon Clark, director of the smokers’ rights group Forest said everybody knew there were risks associated with smoking. “However tobacco is still a legal product which brings a lot of pleasure to many people, including a significant number of doctors. “Government has a role to play educating people about the health risks but in a mature society people should have the freedom to make an informed choice without being patronised or forced to give up.”

Psychological Harm of Quackery

In addition to the unjustified guilt referred to above, cancer patients and their loved ones can be psychologically harmed in several other ways. Misplaced trust. In nearly every case of harm I have examined, misplaced trust either preceded the use of a directly harmful procedure or prevented the patient from obtaining effective care. The deadly message promoted by cancer quackery is that “orthodoxy cannot be trusted.” Undermining trust in the research and therapeutic establishment, the government regulators, and the American Cancer Society is crucial to the promotion of so-called “alternative” approaches to cancer management. A case I investigated from Oregon provides insight into the thinking and actions of “true believers.”

 

A health food store owner discovered a lump in her breast. After diagnosing it as cancer, she boasted to her health food friends that she was “going to prove once and for all that diet cure works!” Unfortunately, although at least 80% of self-discovered breast lumps are benign, hers was cancerous. Her first attempt at self-treatment was to apply the methods in the book The Grape Cure. This book claims that grapes have “powerful” and “antiseptic properties” to help “eliminate evil while building new tissues.” According to the book, “cleansing” and “purification” are accomplished by eating nothing but grapes and grape juice until one stops losing weight. In the second stage, fresh fruits, tomatoes and sour milk may be added to the grape diet. The third stage introduces a wider variety of raw foods, and the fourth stage a ” mixed diet.” After many months, it became apparent that the grape cure had not prevented the tumor from growing. Next, she turned to a popular herbalist in her community who treated her with herbal remedies for about six months without avail.

 

She then went to Mexico for laetrile. Several weeks later, she asked her husband to take her home because laetrile, too, had failed. Her husband looked after her for more than a year before the lesion became so gross and her pain so unbearable that she asked to be taken to a doctor for the first time. She died five days later. The most shocking part of the story is that she went to her grave still believing that she had done the right thing. Her husband, who provided me with the details of the tragedy, also continued to believe in the value of diet cure. He stated that he knows where she went wrong, and that if he gets cancer, will use the dietary treatment correctly. He continued to operate the health-food store, send people to the herbalist, and advocate laetrile. Conversion to deviance. Cancer patients and/or loved ones who accompany them to the cancer treatment underworld may become converted to antisocial behavior. Often these people are encouraged to steer other.

Shortened Chromosomes Linked To Early Stages Of Cancer Development

Scientists at the Johns Hopkins Kimmel Cancer Center say they have evidence that abnormally short telomeres – the end-caps on chromosomes that normally preserve genetic integrity -appear to play a role in the early development of many types of cancer. “Cancer researchers have debated whether shortened telomeres were a cause or effect of tumors,” says Alan K. Meeker, Ph.D., lead author of the study and a postdoctoral fellow in urology and pathology at Hopkins. “What our study suggests is that telomere dysfunction may be a key component in the development of many epithelial cancers, those that arise from tissues lining our organs.” Studying tissue taken from small precancerous lesions in the bladder, esophagus, large intestine, mouth and cervix, the research team found abnormal telomere lengths in 97 percent of the cases examined. In particular, abnormally short telomeres were found in 88 percent of cases. “We were surprised how often you see shortened telomeres this early in the development of these cancers,” says Meeker. “It’s a strong indicator that abnormal telomeres are likely playing a causal role in cancer development.” Telomeres cap the chromosome ends, protecting the interior, gene-containing parts of the chromosome from being accidentally lost. As normal cells divide and age, some of the telomere DNA is lost, and the telomeres get progressively shorter.

 

Normal cells monitor the lengths of their telomeres and initiate cell suicide or halt cell division when telomeres get too short. Other researchers have shown in mice that cancer, which is characterized principally by unrestricted cell growth and lack of cell death, can occur if this monitoring system breaks down, leading to the development of chromosomal abnormalities. “It appears that the telomere shortening frequently observed in large advanced tumors has already occurred before it can be detected by standard diagnostic tools, when cellular changes characteristic of early precancer can only be seen through a microscope by a pathologist,” says Angelo M. De Marzo, M.D., Ph.D., senior author of the study and associate professor of urology, pathology and oncology at Johns Hopkins. “Therefore, intervention strategies aimed at preventing, or even reversing, telomere shortening may be effective in lowering cancer incidence. And assessing telomere length may provide a new direction for cancer prevention studies, and lead to improved early diagnosis of precancerous lesions.”

 

For the study, published in the May 15 issue of the journal Clinical Cancer Research, Meeker, De Marzo and colleagues used a technique called fluorescent in situ hybridization (FISH) to compare telomere length in cells from both precancerous lesions and normal surrounding cells of the bladder, esophagus, large intestine, mouth and cervix. The FISH test uses fluorescent-labeled probes specific for particular locations in DNA and is commonly used to detect or confirm gene or chromosome abnormalities. Chromosomal DNA is first denatured, a process that separates the strands within the DNA’s double helix structure. The Hopkins scientists then added a fluorescent probe specific for telomere regions. As the DNA re-forms into a double helix, it blends with the fluorescent molecules, enabling scientists to examine specific chromosomal locations under a microscope for the level of fluorescence that corresponds to telomere length.

Smoking and binge drinking blamed for rise in mouth cancer

Binge drinking combined with smoking is causing oral cancer in men and women as young as 20, according to a new study. The rise in heavy drinking and smoking among young people – particularly women – has led to a surge in the incidence of mouth cancer for people in their 20s and 30s, according to researchers from King’s College London. Scientists believe that tobacco smoke mixed with alcohol produces dangerous levels of cancer-causing chemicals that attack the lining of the mouth. Oral cancer cases have risen by 17 per cent over the past four years – a faster rate than for any other major cancer. The disease kills 1,700 people a year and that figure is expected to rise sharply over the next 10 years.

 

Most victims of mouth cancer are heavy-smoking older men from poor backgrounds but the King’s College study shows that young men and women in higher social classes – especially those who drink and smoke heavily – are increasingly at risk. The study identified 116 cases of oral cancer in people under 45, of whom 40 per cent were in social classes one or two (the highest). Some patients were as young as 20. The researchers identified heavy smoking and drinking as risk factors in three quarters of the cases. The scientists say it is likely that alcohol is able to dissolve and carry some of the organic poisons, including those from smoking, that have been linked to cancer. Professor Newell Johnson, a professor of oral pathology at King’s College, said: “Our data show that smoking, drinking and poor diet are major risk factors, and that the younger people start smoking and drinking, the higher the risk.”

 

Prof Johnson said that the proportion of younger people with the disease was growing not only in Britain but hroughout western Europe. He described the findings as “important public health information”. David Thomas, the post-graduate dental dean at Oxford University and a consultant in dental public health, said: “There is emerging evidence of a change in the profile of the people getting oral cancer. Partly it’s because there are more women smoking and younger people are binge-drinking as well.” Smoking rates are now increasing in women and nearly one woman in five is drinking more than the amount deemed safe.