Scientists have used a version of the anthrax toxin to kill tumours in mice. The toxin was so effective that after just one treatment, tumours were reduced in size by up to 92%. The technique has been developed by researchers from the US National Institutes of Health. It works by targeting a protein called urokinase which is produced in high levels by cancerous cells. The researchers genetically altered the structure of the anthrax toxin so it only invaded cells that produced high levels of urokinase. Different tumour types The toxin effectively killed several types of tumour cells, without causing any apparent damage to normal tissue. Tumour cells began dying just 12 hours after the first treatment. Two treatment cycles were enough to completely obliterate 88% of a type of tumour called a fibrosarcoma. It also knocked out 17% of a second type of tumour called a melanoma.
However, the toxin did not damage skin cells or hair follicles surrounding the tumour – suggesting that the toxin is highly selective, and may not lead to the severe side effects sometimes associated with alternative treatments. The researchers stress that further research is needed to determine if the engineered anthrax toxin will have similar effects in humans. Lead researcher Dr Steve Leppla told BBC News Online: “The fact that our cytotoxin can successfully kill several different solid tumours suggests it may be even better on leukemias, where the toxin has an easier time reaching every tumour cell. “We are testing that now.” Dr Elaine Vickers, of Cancer Research UK, described the research as very interesting, but warned that it was still at an early stage.
She said more work was needed to discover whether the technique worked in humans, and to confirm that it did not damage healthy cells. “Molecules that are over-produced by cancer cells are very interesting as targets for developing new cancer treatments, hopefully with fewer of the side-effects associated with more conventional therapies. “However, it is essential that the molecule targeted by the treatment is exclusively over-produced by cancer cells to avoid damage to healthy tissue. “This is particularly important if a potent toxin, such as the anthrax toxin being investigated in this research, is being used to kill the cancer cells.” The research is published in the Proceedings of the National Academy of Sciences.
Cigarette smoke transforms healthy saliva into a deadly cocktail that can accelerate mouth cancer, according to research in the British. New research shows that the chemicals in tobacco smoke combine with saliva with devastating effect. They destroy the protective components of saliva – leaving a corrosive mix that damages cells in the mouth and can eventually turn them cancerous. There are nearly 8,000 cases and 3,000 deaths from mouth cancer in the UK every year – the main cause being smoking. Mouth cancer can develop in any part of the mouth including the tongue, gums, lining of the mouth and lips. The researchers in the study wanted to examine saliva’s role in the development of mouth cancer. Around 90 per cent of lung cancer cases are caused by tobacco smoking and other studies show that smoking can cause a range of other cancers including cancer of the pancreas, stomach, liver and lower urinary tract. The study recreated the effects of cigarette smoke on cancerous cells of the mouth.
Women who smoke and who are infected with genital warts have a much higher risk of genital cancer than other women. One particular strain of wart virus known as HPV16 increased the risk of cancer by six times in smokers, Margaret Madeleine and colleagues at the Fred Hutchinson Cancer Research Center in Seattle reported Tuesday. “This is supportive evidence that HPV16 is particularly important for vulvar cancer,” Madeleine said.
The anticancer research group of combining traditional Chinese and Western medicine (including 3 doctors,2 masters and 3 physicians-in-charge) has carried on a general study on a folk prescription more than one year and achieved a major breakthrough in the field of cancer treatment.The basic study reveals that the Chinese prescription has a lower toxicity, a higher inhibitory rate to the tumor and obvious effect of enhancing the body’s immunity (see data 3).
New drugs that target cancer in unique ways, including a substance extracted from licorice root and an anti-tumor bomb made from the Salmonella bacteria, may add some specialized weapons to the arsenal, doctors said. So far only a few of the very sickest patients have been helped, and most of them only lived a few months longer than they would have without the treatment. But experts say the drugs offer a targeted approach to cancer and may allow for more tailored treatments. Dr. Daniel von Hoff, president of the American Association of Cancer Research (AACR), said the patients tested were dying despite getting the best treatment available. “You have some agent that hits a specific target in patients who have already progressed on all other therapies,” he said in an interview on Tuesday.
Renal Cell Cancer is one of the rarer cancers. It dose not respond to Chemotherapy, it dose not respond to radiation-therapy and there is only limited response to immune-therapy (Interferon etc.). Renal Cell Cancer is an immune system cancer therefore everything you can do to help your immune system helps the fight, do exercise, do keep your weight under control, do keep a positive attitude, protect the remaining kidney, drink lots of water keep a low sodium diet, exercise.