Anthrax as a cancer treatment

Scientists have used a version of the anthrax toxin to kill tumours in mice. The toxin was so effective that after just one treatment, tumours were reduced in size by up to 92%. The technique has been developed by researchers from the US National Institutes of Health. It works by targeting a protein called urokinase which is produced in high levels by cancerous cells. The researchers genetically altered the structure of the anthrax toxin so it only invaded cells that produced high levels of urokinase. Different tumour types The toxin effectively killed several types of tumour cells, without causing any apparent damage to normal tissue. Tumour cells began dying just 12 hours after the first treatment. Two treatment cycles were enough to completely obliterate 88% of a type of tumour called a fibrosarcoma. It also knocked out 17% of a second type of tumour called a melanoma.

 

However, the toxin did not damage skin cells or hair follicles surrounding the tumour – suggesting that the toxin is highly selective, and may not lead to the severe side effects sometimes associated with alternative treatments. The researchers stress that further research is needed to determine if the engineered anthrax toxin will have similar effects in humans. Lead researcher Dr Steve Leppla told BBC News Online: “The fact that our cytotoxin can successfully kill several different solid tumours suggests it may be even better on leukemias, where the toxin has an easier time reaching every tumour cell. “We are testing that now.” Dr Elaine Vickers, of Cancer Research UK, described the research as very interesting, but warned that it was still at an early stage.

 

She said more work was needed to discover whether the technique worked in humans, and to confirm that it did not damage healthy cells. “Molecules that are over-produced by cancer cells are very interesting as targets for developing new cancer treatments, hopefully with fewer of the side-effects associated with more conventional therapies. “However, it is essential that the molecule targeted by the treatment is exclusively over-produced by cancer cells to avoid damage to healthy tissue. “This is particularly important if a potent toxin, such as the anthrax toxin being investigated in this research, is being used to kill the cancer cells.” The research is published in the Proceedings of the National Academy of Sciences.

Cigarette smoke transforms healthy saliva into a deadly cocktail

Cigarette smoke transforms healthy saliva into a deadly cocktail that can accelerate mouth cancer, according to research in the British. New research shows that the chemicals in tobacco smoke combine with saliva with devastating effect. They destroy the protective components of saliva – leaving a corrosive mix that damages cells in the mouth and can eventually turn them cancerous. There are nearly 8,000 cases and 3,000 deaths from mouth cancer in the UK every year – the main cause being smoking. Mouth cancer can develop in any part of the mouth including the tongue, gums, lining of the mouth and lips. The researchers in the study wanted to examine saliva’s role in the development of mouth cancer. Around 90 per cent of lung cancer cases are caused by tobacco smoking and other studies show that smoking can cause a range of other cancers including cancer of the pancreas, stomach, liver and lower urinary tract. The study recreated the effects of cigarette smoke on cancerous cells of the mouth.

 

Half the cell samples were exposed to cigarette smoke and the other half to the saliva and cigarette smoke mixture. Cancerous cells were used in order to assess quickly whether the saliva and smoke mixture would speed the cancer’s development. The study revealed that the longer the mouth cells were exposed to the contaminated saliva, the more the cells were damaged. Dr Rafi Nagler of the Technion-Israel Institute of Technology, who co-led the study, says: “Most people will find it very shocking that the mixture of saliva and smoke is actually more lethal to cells in the mouth than cigarette smoke alone. “Our study shows that once exposed to cigarette smoke, our saliva not only loses its beneficial qualities but it turns traitor and actually aids in destroying the cells of the mouth and oral cavity.” Saliva contains anti-oxidants.

 

These are molecules that can help protect the body against cancer. The researchers found that the cigarette smoke destroyed them and turned saliva into a dangerous cocktail of chemicals that could accelerate the development of mouth cancer. Control for Cancer Research UK said “Once more we see the dreadful impact smoking can have on health. This insight into how mouth cancer can develop offers more reasons for smokers to try and quit. People know of the link with lung cancer, and this research adds compelling evidence about the damage smoking can do to the mouth.”

Women who smoke and who are infected with genital warts have a much higher risk of genital cancer than other women

Women who smoke and who are infected with genital warts have a much higher risk of genital cancer than other women. One particular strain of wart virus known as HPV16 increased the risk of cancer by six times in smokers, Margaret Madeleine and colleagues at the Fred Hutchinson Cancer Research Center in Seattle reported Tuesday. “This is supportive evidence that HPV16 is particularly important for vulvar cancer,” Madeleine said.

 

Writing in the Journal of the National Cancer Institute, Madeleine’s team said they are checking on a reported increase in the rate of non invasive cancer of the vulva–the external female genitals. Cervical and Vulvar Links Smoking and wart virus are also linked with cervical cancer, but the link with vulvar cancer was more controversial. Madeleine’s team worked with 510 women in the Seattle area who had cancer of the vulva and 1,400 women who did not. They checked them for three types of wart virus–HPV-6, HPV16 and HPV18–as well as genital herpes infection. Women who had never smoked but who had HPV16 had 2.9 times the risk of vulvar cancer as opposed to uninfected women who never smoked. Smokers who were free of the virus had a 4.9 times greater risk of vulvar cancer. But women who both smoked and had HPV16 infection had 18.8 times the risk of cancer.

 

“They seem to work in synergy,” Madeleine said. “It’s more than you would expect to see just from smoking or having the virus by itself.” Madeleine said neither HPV-6 nor HPV-18 had the same effect. Genital wart virus is fairly common–infecting up to 20 percent of young women volunteering for clinical studies. Madeleine said most of the infected women probably caught the virus soon after becoming sexually active. “It’s current smoking in the presence of the infection that magnifies the risk,” she said. Infection with genital herpes also slightly increased the risk of vulvar cancer.

Head and Neck Cancer

Approximately 30,200 patients will be diagnosed with squamous cell cancers of the oral cavity and pharynx in the year 2000. Of these, an estimated 7,800 patients will present with metastases or develop recurrent disease, which is not amenable to surgery or radiation therapy. Palliative chemotherapy is thus the only treatment option. Traditionally, combinations of cisplatin and 5-fluorouracil have been used as first line agents, with median times to progression of 2.5 to 3 months and median survival rates 5 to 7 months.

 

New treatment strategies for head and neck cancer are currently underway, using novel agents including antiangiogenesis compounds. One such antiangiogensis compound is Tetrathiomolybdate. New modalities of treatment called “anti- angiogenic” and “cytokine modulation” are being tested in cancer patients. Cancer cells need a good blood supply to grow, this concept is called angiogeneisis. Anti-angiogenic therapy attempts to stop cancer growth by preventing the development of new blood vessels. Cytokines are another class of chemicals that regulate tumor growth. Cytokine modulation therapy attempts to stop cancer growth by interfering with the production or action of these chemicals.

 

Tetrathiomolybdate is a drug that may treat cancer through both an “anti-angiogenic” and a “cytokine modulation” approach. TM is thought to do this by depleting the element copper from cells. Copper is thought to be required for both angiogenesis and the production of cytokines. Without angiogenesis and cytokines we believe the cancer cells cannot grow. This drug has been given to patients with breast, lung, and kidney tumors. We now wish to see if this drug will be effective in patients with metastatic/unresectable head and neck cancers.

The business of breast cancer

Funding for breast cancer research by the National Institutes of Health rose to more than $600 million in 1999, up from just $90 million in 1991. Women participate more actively in decisions about their medical care, more of them receive breast-conserving lumpectomies than in the past and survival rates have gone up. And some women’s advocates have made it onto important policymaking panels. But the authors spend most of their time hashing out the societal, social and scientific problems surrounding breast cancer. Unfortunately, they write in a consistently academic tone that weakens their message and may make the book less compelling for the layperson whose attention they appear to be seeking. The prevailing gripe of the book, which is repeated ad nauseam, is that the majority of the funding is channeled into research that focuses on a biomedical approach to preventing and treating cancer (genetics, chemotherapy and surgery), rather than research that examines the environmental factors, like pollution and toxic waste, that these authors believe contribute to breast cancer.

 

“Efforts to encourage research and advocacy into possible environmental causes — including corporate pollution — have met with stiff resistance and meager funding, not to mention potential conflict of interest,” writes sociologist Jane Zones in her essay “Profits From Pain: The Political Economy of Breast Cancer.” Another writer cites studies that indicate links between breast cancer rates and hazardous-waste sites, industrial pollution, pesticides like DDT, chemicals like PCBs (an organic chemical used in industry) and products like polyvinyl chloride (known as PVC or vinyl).

 

Although she picks and chooses studies that support her position, the evidence is compelling enough to make an effective case for further research. Several authors contend that society shirks its responsibility for preventing breast cancer, placing it instead on the individual woman — from her diet to her genes to her reproductive life. In an essay on women’s magazines’ coverage of breast cancer, three coauthors write, “Ultimately, the magazines send the message that women can locate the causes of breast cancer in either their lifestyle behaviors or in their bodies. Breast cancer then becomes a personal problem rather than a social issue.”

Aspirin as a life extender

Aspirin is over 100 years old Aspirin may protect against cancers of the mouth, throat and oesophagus, a study suggests. Researchers in Italy say taking aspirin regularly for five years cuts the risk of contracting these diseases by two thirds. The findings add to growing evidence that aspirin truly is a miracle drug. Previous studies have shown that the pill, developed more than 100 years ago, may help prevent bowel and lung cancer. While most people take it to relieve pain, it is also widely used to protect against heart disease and even arthritis. Analysis Reports of its latest therapeutic benefits follow a study by scientists from the Institute of Pharmacological Research in Milan.

 

They analysed information from three separate studies involving 965 cancer patients and 1779 people who were in hospital for other conditions. Everyone in the studies filled in detailed questionnaires about smoking and drinking habits, diet and how often they took aspirin. They found that people who had taken aspirin regularly for five years or more cut their chances of developing cancers of the mouth, throat and oesophagus by two thirds compared to those who didn’t take the medicine. Many of the aspirin users in the study had been taking the drug because they had been diagnosed with other health problems, such as heart disease. The scientists believe that if people started taking the drug earlier, specifically for its anti-cancer properties, it might be possible to achieve even stronger protective effects.

 

However, further research will be needed to evaluate this and to track possible side-effects of long-term aspirin use. But lead researcher Dr Cristina Bosetti hailed the findings. “This is the first quantitative evidence that taking aspirin may reduce the risk of developing cancers in what we call the aerodigestive tract, connecting the mouth and the stomach. “We think that aspirin may take effect by acting on an enzyme called cyclooxegenase-2, which has a role both in inflammation and the process of cancer growth. “Our results further extend our knowledge of the health benefits of this remarkable drug and suggest that taking it could become an important way of protecting ourselves against cancer.”

Great Breakthrough for Cancer Treatment

The anticancer research group of combining traditional Chinese and Western medicine (including 3 doctors,2 masters and 3 physicians-in-charge) has carried on a general study on a folk prescription more than one year and achieved a major breakthrough in the field of cancer treatment.The basic study reveals that the Chinese prescription has a lower toxicity, a higher inhibitory rate to the tumor and obvious effect of enhancing the body’s immunity (see data 3).

 

The clinical data shows that the relieving rate (CR+PR)and the effective rate (CR+PR+MR) for treatment with this prescription are 35% and 50% ;and those for treatment with combination of Chinese and Western medicine are 50% and 85% respectively when the cancer is in the middle and advanced stages . The survival quality scores (Karnofsky method) are 59 before taking the folk prescription and 73 after taking it for a month . Moreover there is no narrow inhibition and harm to the liver and kidney functions(see data No:2). It is found that the Chinese medicine has a tremendous potential in treatment of cancer in these studies.

 

In order to exert this prescription’s role completely in treatment of cancer and relieve the sufferings for more cancer cases,we sincerely hope that all the friends at home and abroad come to invest and develop this prescription, so as to establish a comprehensive cancer research and treatment institute at the basis of preparation development ,and really come up to a first-rate curative effect of treating cancer with traditional Chinese and Western medicine.We believe that cancer will be treated easily just as tuberculosis is cured after several years’ efforts.

Licorice Root extract fights Cancer

New drugs that target cancer in unique ways, including a substance extracted from licorice root and an anti-tumor bomb made from the Salmonella bacteria, may add some specialized weapons to the arsenal, doctors said. So far only a few of the very sickest patients have been helped, and most of them only lived a few months longer than they would have without the treatment. But experts say the drugs offer a targeted approach to cancer and may allow for more tailored treatments. Dr. Daniel von Hoff, president of the American Association of Cancer Research (AACR), said the patients tested were dying despite getting the best treatment available. “You have some agent that hits a specific target in patients who have already progressed on all other therapies,” he said in an interview on Tuesday.

 

“To see anybody respond in that situation is a triumph.” The AACR, along with the National Cancer Institute (NCI) and the European Organization for Research and Treatment of Cancer (EORTC) highlighted the experimental drugs at a meeting on basic cancer research. One study shows that a compound found in licorice root, licochalcone-A, can work against acute leukemia, breast and prostate cancer tumors, at least in laboratory dishes. Researchers said it lowers levels of bcl-2, a drug-resistant protein, in the tumors. “By decreasing the level of bcl-2, licochalcone-A may increase tumor sensitivity to anti-cancer agents,” Dr. Robert DiPaola of the Robert Wood Johnson Medical School in New Brunswick, New Jersey, said in a statement. The extract seems to act as a phytoestrogen — a plant version of the hormone estrogen, known to be involved in many cancers, DiPaola told the meeting. Another experimental drug highlighted at the meeting was AstraZeneca’s Iressa, known also by the experimental name ZD1839.

 

A member of a new class of drugs known as signal transduction inhibitors, it works by blocking signals within the tumor cells, stopping the process by which the cells can proliferate. Iressa targets in particular pathway — a series of biochemical events in the cells — kicked off by a hormone known as epidermal growth factor (EGF). “The hypothesis … is that if we can successfully block the EGF receptor … cancer will be arrested,” Dr. Mark Kris of Memorial Sloan Kettering Cancer Center in New York told the meeting. They tried Iressa on 64 patients whose cancer was getting worse despite treatment at four hospitals in the United States and Britain. They got varying doses of Iressa for 14 days. Four had what were classed as “major responses,” meaning their disease stabilized, for anywhere between 2 and 9 months.

Renal Cell Cancer

Renal Cell Cancer is one of the rarer cancers. It dose not respond to Chemotherapy, it dose not respond to radiation-therapy and there is only limited response to immune-therapy (Interferon etc.). Renal Cell Cancer is an immune system cancer therefore everything you can do to help your immune system helps the fight, do exercise, do keep your weight under control, do keep a positive attitude, protect the remaining kidney, drink lots of water keep a low sodium diet, exercise.

 

This is My Personal opinion only, Renal cell Cancer is NOT curable it is only a matter of how long YOU can keep it in remission, it will return someday. There has been a slow but steady improvement in the treatment and the longer you can stay in remission the better the odds are that you can continue the fight. Find a good Oncologist, one that you feel comfortable with and that you trust if You do not feel comfortable change, this is someone you will develop a unique relationship with and YOU MUST feel comfortable with it.

 

Do find an excellent Cancer Treatment center, I prefer a NOT for profit center, I am always a bit skeptical of medical centers that have bottom line goals. I am certain this was not what you wanted to hear and perhaps you will be lucky and it will not be Renal Cell Cancer. If it is at least you know that some of us are able to keep on fighting. The gloomy survival numbers are not always true I am at 11 years and counting.

Ginger could halt bowel cancer

Ginger is well known for its health benefits Ginger may protect against bowel cancer, scientists have claimed. Test showed gingerol – which gives ginger its flavour – could slow the growth of human tumours in mice. Plants from the ginger family have been used for thousands of years, and have been reported to have anti-cancer properties. A second study presented to the American Association of Cancer Research showed a relative of mint could slow prostate cancer. These results strongly suggest that ginger compounds may be effective chemopreventive and/or chemotherapeutic agents Dr Ann Bode, University of Minnesota Researchers from the University of Minnesota’s Hormel Institute in Austin, fed half a milligram of [6]-gingerol to mice genetically engineered not to have an immune system three times a week before and after they were injected with human bowel tumour cells.

 

Other mice were injected with the tumour cells — but were not given the gingerol. Tumours were allowed to grow until they reached a size of one cubic centimetre (0.06 cubic inch), after which the mice were put to sleep. After 15 days, 13 tumours of a measurable size had appeared amongst the control mice, but only four amongst the mice given the gingerol. By day 28, all the mice in the control group had measurable tumours, but it took 10 more days for all but one of the gingerol group to develop measurable tumours. By day 49, all the control mice had been killed because they had developed tumours of one cubic centimetre or more, but 12 of the gingerol mice were still alive and their average tumour size was about half the maximum allowable size.

 

Dr Ann Bode, who led the research, said: “Plants of the ginger family have been credited with therapeutic and preventive powers and have been reported to have anti-cancer activity. “The substance called [6]-gingerol is the main active compound in ginger root and the one that gives ginger its distinctive flavour.” She added: “These results strongly suggest that ginger compounds may be effective chemopreventive and/or chemotherapeutic agents for colorectal carcinomas.”